Genomic analysis reveals allele-specific RNA editing phenomena July 18, 2018 Source: Science and Technology Daily RNA (RNA) editing is a common modification of RNA levels and an important form of increasing gene transcription and functional diversity. On the 17th, from the Kunming Institute of Zoology of the Chinese Academy of Sciences, a team led by academician Zhang Yaping and a number of research institutions joined the team to make important progress in allele-specific RNA editing research. Dr. Zhou Zhongyin from the Kunming Institute of Zoology, Chinese Academy of Sciences, introduced that for diploid organisms, although the regulation of the expression of two alleles is critical for development and is associated with some diseases, existing studies have shown that many genes are expressed as single The allele is highly expressed. Among them, allele-specific methylation is one of the important reasons for the generation of allele-specific expression, but the existing research mainly focuses on the DNA level. Since RNA plays a leading role in transcription and translation, various RNA modifications have been reported successively, but whether the modification at the RNA level in the organism is characterized by allele-specific modification has not been studied. A team led by Academician Zhang Yaping studied allele-specific RNA editing in human and mouse tissues. They identified 315 allele-specific RNA editing sites in the human body, and these sites have a considerable overlap in different tissues. At the same time, they used distant hybridized mice to identify 184 allele-specific RNA editing sites and found that there is a considerable overlap in the different hybrid combinations, which means that the identification method is credible, and It is proved that allele-specific RNA editing is widespread, and cell-level mutation experiments reveal that these synonymous mutation sites affect the efficiency of RNA editing. Further experiments revealed that DNA sequence polymorphism at the genomic level produces allele-specific RNA editing by affecting RNA secondary structure. This work provides a successful paradigm for allele-specific RNA editing studies and provides new insights into the interpretation of synonymous mutations associated with disease and trait changes. The results have been published online in the internationally authoritative journal Nucleic Acids. . (Reporter Zhao Hanbin) Dual Lens Flood Light Camera,Wireless Wifi Cctv Camera,1080P Camera,Security Surveillance Camera Shenzhen Zuomi Technology Co., Ltd. , https://www.bkvis.com