The ratio of human cells to bacteria living inside and on the surface of the human body is about 1:1.3. It is not an exaggeration to say that human beings are colonies of bacteria.

In addition to being affected by its own genetic regulation and environmental factors, the human body's physiological health status must be ignored. Another major influencing factor is the large population of bacteria that coexist with the human body. Most of these bacteria live in the human gut, and they are collectively referred to as the intestinal flora.

The genes of human beings are innately determined. In addition to the technical difficulties, the genes that change the human body may also involve ethical issues. However, the use and modification of the intestinal flora will have a beneficial effect on human health, which is increasingly subject to scientific research. Circle and industry attention.

Numerous studies have shown that in addition to intestinal inflammation, intestinal microbes are associated with diseases such as obesity, diabetes, cardiovascular disease, cancer, rheumatoid arthritis, and depression. The application research and industrial transformation of a large number of intestinal microorganisms in the clinical direction are in the ascendant.

As with the 1% Human Genome Project, in 2008, the participation of Huada Gene in the EU-initiated Human Intestinal Metagenomics Program (MetaHIT) can be said to be the starting point of Chinese microbiology research and the starting point of spectrum technology (multiple members). Participated in this research project).

Young scientists represented by Wang Jun and Qi Junjie have played an extremely important role in this project, and have carried out many basic and pioneering work for the research and development of microbiology in China. At that time, there were teams in Europe who were involved in and related work. At that time, as the project leader of the PhD student's founder of the elementary technology, Yan Junjie led a group of young and energetic young people to race around the European team to reveal the human intestinal flora.

Yan Junjie recalled: "From the perspective of micro-ecology, I was a new layman, but relying on the world's leading technology platform, some of them are 'unscrupulously' open up. It is the omics technology represented by the second generation sequencing. After being closely integrated with microecology, microbiology was born."

In this program, they discovered more than 1,000 human intestinal resident genes and more than 3.3 million bacteria. Not satisfied with treating the gut microbiota as an isolated individual, Yan Junjie led the team to interpret the human gut flora from the perspective of human disease. Hard work pays off, they found a close relationship between the intestinal flora and type 2 diabetes, this is just the beginning of the indissoluble bond between Yan Junjie and his team and micro-ecological health.

Eight years later, from the original micro-ecological outsider, Yan Junjie not only became a leader in domestic and even global scientific research systems in the micro-ecology field, but also transformed into an entrepreneur who can sensitively perceive industry trends and cope with more complex and diverse challenges. The spectrum technology he founded has become a leader in the field of micro-ecology.

Leave the big tree of Huada Gene and open up the microbial forest

When leaving Huada Gene, with the support of Wang Jun and Wang Jian, Chairman of Huada Gene, Yan Junjie has established functional units such as microbiological information analysis, live bacteria screening and culture, animal models, probiotics/prebiotics product transformation. . He has created a platform that is ahead of the world.

When talking about leaving the Chinese gene, Yan Junjie said: "Intuition tells me that new technology will promote the rapid development of the micro-ecological industry. I want to devote myself wholeheartedly and decently to this industry, just like using my life to complete one piece. artwork."

In July 2014, Spectrum Technology was established, and Jun Junjie successfully transformed from an academic who was fascinated with academics into an entrepreneur who fought in the business world. Thanks to the solid scientific research training and deep technical accumulation, Spectrum Technology attaches great importance to R&D and regards core technology as the lifeline of the company. In the research and development of the spectrum, the Shenzhen Spectrum Element Research Institute and the Shenzhen Spectrum Medical Laboratory were established. Through cooperation with well-known domestic and overseas scientific research institutions, the use of project research and development to promote scientific research and transformation, and achieve the "production, learning, research" linkage.

Spectrum Technology adopts advanced microbiome technology and is committed to technology development and product application in three areas of technology services, micro-ecological health and clinical testing. There are three main product lines:

First, technical services cover many fields such as medicine, health, agriculture, and environment. For example, in the medical field, with the aim of precise diagnosis and precise treatment of diseases, research on the role of the human microbiome in developing micro-ecological detection and micro-ecological treatment solutions; in the field of health, from the intestinal flora From a health perspective, we can evaluate the efficacy of various health foods and health programs; in agriculture, we can develop the value of microorganisms in crop growth and animal husbandry; in the environmental field, we conduct environmental monitoring through microorganisms, and use microbes for environmental pollution control and ecological restoration. The spectrum provides more than just sequencing, and a complete micro-ecological technology solution. Relying on a strong research and technical team, Spectrum can provide a full-process business from technical solution design to analysis report and product design.

The second is to develop personalized intestinal health management services based on microbiological health products. Based on industry-leading technology and market cooperation based on extensive upstream and downstream industry chains, Spectrum Technology has built a database of life and health to provide intestinal flora, skin flora, oral flora and genital flora for Chinese people. Multi-dimensional metagenomic detection and personalization of intervention products. At present, Spectrum Technology has cooperated with many top three hospitals and health management companies in COFCO Nutrition Research Institute, Beishangguangshanghang and other places to complete the construction from R&D to industrialization, so that the research and development results can be faster. Push to commercialization.

The third is the clinical direction. It can provide rapid detection of pathogenic microorganisms and accompanying detection of intestinal flora for medical and scientific research institutions, assist precision medicine, and provide more advanced and accurate personalized treatment for each patient.

High standard database, strong human resources support rich product line

In database construction, in addition to focusing on the order of magnitude of data, spectral element technology has made horizontal extensions, such as data output standards, data mining algorithms, and data interpretation knowledge bases, leading the industrialization process in this field.

In 2017, Spectrum has established a cooperation with the Chinese Academy of Medical Oncology Hospital and the National Cancer Center. The US standard has been used to comprehensively evaluate the data output process of the spectral elements. The results show that the data output process of the spectral elements is internationally leading. It proves the deep accumulation of spectrum technology in data output, data mining, data interpretation and the world's leading technology.

In the process of industrialization around the intestinal flora, the spectrum established an independent microbiome testing laboratory and a gut flora testing production line. To address the needs of large-scale inspection and data analysis.

In terms of talent development, Spectrum has a professional team to support scientific design. Some of the team members were born in the same way as Jun Junjie, and some graduated in person. The team has 10 years of experience in microbiome analysis, the first gut microbiota team, and the citation rate exceeded 4,500. Moreover, the team advocates the spirit of innovation and is not satisfied with the existing technology. Since 2016, it has upgraded the microbiome technology and established a new technology platform for multi-disciplinary, individualized and big data.

Since its establishment four years ago, Spectrum Technology has been established in 2014 to achieve self-financing. In 2015, it developed products and achieved first round financing in 2016. In 2017, the software and hardware construction, such as the microbiological testing platform, passed the ISO standard and the US MBQC project evaluation. In 2018, for the spectrum element, it will be a new first year. This year, the spectrum will usher in a comprehensive upgrade of the existing product line, and at the same time launch a number of new products closely related to public health.

Endogenous problems in the micro-ecology industry, bringing challenges and unlimited opportunities

The micro-ecological field is hot in foreign countries, and the domestic benefit from the pursuit of capital and downstream markets is also in a state of rapid follow-up. However, Yan Junjie also bluntly stated the impetuous problems in the industry.

He said: "I think the status quo is that the script is there, the stage is set up, and it depends on how the actors perform. To say what is missing, I think that compared with foreign countries, the country is similar and not like God. It lacks both inner things. It’s probably not too big a problem to look at in the country, because there is capital and market support.”

Although the domestic market is bullish, Yan Junjie believes that the endogenous problems in the entire industry, that is, the challenge to the spectrum, also brought a huge opportunity for the spectrum.

He said: "Reference to the development of the probiotic industry, I believe that the micro-ecological related industries will eventually become international. If we do not pay attention now, we may find in the micro-ecological industry, instruments, reagents, algorithms, strains, drugs, etc. Can only use foreign, or foreign products work best."

How to seize the gimmick in the international micro-ecological market and increase China's own core competitiveness in this field. Yan Junjie believes that the focus is still on innovation. “We need to work harder on innovation, not just technological innovation, but also innovation in business models.”

He believes that the market now needs a benchmarking company that has the ability to integrate the industry. “The cooperation between upstream and downstream enterprises in the micro-ecological industry is not too close. From science education, market propaganda to inspection and tracking, intervention and conditioning, this is a big industrial chain, and it is necessary for capable enterprises to integrate this ecosystem.”

In the future, technology will be used as an engine to create a digital platform around the intestinal flora.

Speaking of the future development of the intestinal flora, Yan Junjie said that there is still a lot of room for the future intestinal flora to improve health services. In the future, the management of intestinal flora will be contextualized and ecological, and a digital platform will be built around the intestinal flora.

Yan Junjie thought about the four major application scenarios:

1, applied to chronic disease management: high-risk groups, and even ordinary people can carry out personalized intervention of intestinal flora in advance, killing the chronic diseases of today's society in the cradle.

2, the use of smart equipment: take the pills, directly in the digestive tract to monitor your intestinal flora, and its metabolites and other important health indicators.

3, smart home environment: smart kitchen, personalized diet, especially the probiotics and prebiotics as a daily supplementary food, enter our daily three meals; smart toilet (will be oral, skin, urine and other samples tested The main place will automatically collect and detect when we brush our teeth, wash our face, take a bath, and conveniently provide health data. Intelligent devices such as air conditioners and water dispensers will always monitor whether breathing air and drinking water are healthy and safe.

4, intestinal flora maintenance: through the flora transplantation, micro-ecological capsules and other methods to carry out the "initialization" of the intestinal flora.

“At that time, everyone was not only concerned about the weather forecast, but also their own intestinal health predictions,” he said. This is based on the data of its own genes, intestinal flora, daily life, diet and exercise information, and comprehensive analysis and warning for individual health.

Based on the intestinal flora, in addition to the above-mentioned exploration that makes the body healthier and longer, the spirit is more pleasant, and the brain is more intelligent, the huge treasure house of bacterial metabolites needs to be developed in the future. To this end, Spectrum Technology will also increase distribution, expand commercial channels, increase the influence of the spectrum brand; carry out international cooperation, fully play and dominate China's advantages and status in this field.

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