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Product Name:Â Â Â Â Everolimus
CAS RN.:Â Â Â Â 159351-69-6
EINECS:Â Â Â Â Add
Molecular Weight:Â Â Â Â 958.2244
Molecular Formula:Â Â Â Â C53H83NO14
Density:Â Â Â Â 1.18g/cm3
Boiling Point(ºC):    998.7°C at 760 mmHg
Flash Point(ºC):    557.8°C
Refractive_index:Â Â Â Â 1.548
Description
Everolimus  is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycinÂ
It is currently used as an immunosuppressant to prevent rejection of organ transplants and treatment of renal cell cancer and other tumours. Much research has also been conducted on everolimus and other mTOR inhibitors as targeted therapy for use in a number of cancers.
Inhibition of mTOR, the molecular target of Everolimus, extends the lifespan of model organisms including mice, and mTOR inhibition has been suggested as an anti-aging therapy.
 
Functions
Role in heart transplantation
Everolimus may have a role in heart transplantation, as it has been shown to reduce chronic allograft vasculopathy in such transplants. It also may have a similar role to sirolimus in kidney and other transplants.
Role in liver transplantation
Although, sirolimus had generated fears over use of m-TOR inhibitors in liver transplantation recipients, due to possible early hepatic artery thrombosis and graft loss, use of everolimus in the setting of liver transplantation is promising.  Also, a possible role of everolimus in reducing the recurrence of hepatocellular carcinoma after liver transplantation was correlated.
Use in vascular stents
Everolimus is used in drug-eluting coronary stents as an immunosuppressant to prevent restenosis. Abbott Vascular produce an everolimus-eluting stent (EES) called Xience Alpine. It utilizes the Multi-Link Vision cobalt chromium stent platform and Novartis' everolimus.Â
Use in aging
Inhibition of mTOR, the molecular target of Everolimus, extends the lifespan of model organisms including mice,and mTOR inhibition has been suggested as an anti-aging therapy. Everolimus treatment of mice results in reduced metabolic side effects compared to sirolimus.
Side effect
The most common adverse reactions (incidence greater than or equal to 30%) were stomatitis, infections, diarrhea, peripheral edema, fatigue and rash. The most common blood abnormalities found (incidence greater than or equal to 50%) were anemia, hypercholesterolemia, lymphopenia, elevated aspartate transaminase (AST) and fasting hyperglycemia.".
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Our advantage
1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
                     Â
Details
Product Name:Â Â Â Â Everolimus
CAS RN.:Â Â Â Â 159351-69-6
EINECS:Â Â Â Â Add
Molecular Weight:Â Â Â Â 958.2244
Molecular Formula:Â Â Â Â C53H83NO14
Density:Â Â Â Â 1.18g/cm3
Boiling Point(ºC):    998.7°C at 760 mmHg
Flash Point(ºC):    557.8°C
Refractive_index:Â Â Â Â 1.548
Description
Everolimus  is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycinÂ
It is currently used as an immunosuppressant to prevent rejection of organ transplants and treatment of renal cell cancer and other tumours. Much research has also been conducted on everolimus and other mTOR inhibitors as targeted therapy for use in a number of cancers.
Inhibition of mTOR, the molecular target of Everolimus, extends the lifespan of model organisms including mice, and mTOR inhibition has been suggested as an anti-aging therapy.
Â
Functions
Role in heart transplantation
Everolimus may have a role in heart transplantation, as it has been shown to reduce chronic allograft vasculopathy in such transplants. It also may have a similar role to sirolimus in kidney and other transplants.
Role in liver transplantation
Although, sirolimus had generated fears over use of m-TOR inhibitors in liver transplantation recipients, due to possible early hepatic artery thrombosis and graft loss, use of everolimus in the setting of liver transplantation is promising.  Also, a possible role of everolimus in reducing the recurrence of hepatocellular carcinoma after liver transplantation was correlated.
Use in vascular stents
Everolimus is used in drug-eluting coronary stents as an immunosuppressant to prevent restenosis. Abbott Vascular produce an everolimus-eluting stent (EES) called Xience Alpine. It utilizes the Multi-Link Vision cobalt chromium stent platform and Novartis' everolimus.Â
Use in aging
Inhibition of mTOR, the molecular target of Everolimus, extends the lifespan of model organisms including mice,and mTOR inhibition has been suggested as an anti-aging therapy. Everolimus treatment of mice results in reduced metabolic side effects compared to sirolimus.
Side effect
The most common adverse reactions (incidence greater than or equal to 30%) were stomatitis, infections, diarrhea, peripheral edema, fatigue and rash. The most common blood abnormalities found (incidence greater than or equal to 50%) were anemia, hypercholesterolemia, lymphopenia, elevated aspartate transaminase (AST) and fasting hyperglycemia.".
Â
Our advantage
1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
                     Â
Model NO.: 159351-69-6
CAS: 159351-69-6
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 2937290090
Model NO.: 159351-69-6
CAS: 159351-69-6
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 2937290090
Details