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In recent years, with the rapid development of international inhalation toxicology, accompanied by the development of toxicology in the domestic environment, health, medicine, etc., more and more inhalation experiments have begun. According to the author's contact and understanding with many domestic inhalation and poisoning laboratories this year, most of the laboratories have such problems in the process of inspecting, selecting, planning, and negotiating procurement of inhaled poisoning equipment. For those laboratories who are preparing to start inhaling the inhalation test or preparing to purchase inhalation equipment, it is easy to choose the right price, type, and safe operation equipment. I will only propose myself to use or purchase the inhalation system. Comments and suggestions for your reference.
First of all, what we need to know is a set of suitable inhalation exposure experimental equipment, which is based on the type and number of experimental animals, the physical and chemical properties of the infected substances, the way of exposure, the parameters to be monitored during the exposure process, and Tailor-made services and products are provided for the recycling or treatment of the poisoned substances. At the same time, it is necessary to ensure the convenience of the experimental operation and to ensure the safety of the personnel and the environment during the experiment.
The term "inhalation" is derived from the English word "Inhalation". The term refers only to exposure to the nose and mouth, and because the drug has become a specialized technology, it is mature in inhalation exposure technology. In the future, internationally, Inhalation is generally referred to as the poisoning technology. However, only the principle and method of experimentation, we call it exposure may be more appropriate, which is more and more recognized internationally. For example, CULTEX, the originator of German cell infection, said Its products are: CULTEX ® Exposure; the famous Japanese instrument research and development company SIBATA classifies its products as: Whole bady Exposure and Nose only Exposure. In this way, we can classify the infected equipment differently, such as according to the exposed parts and methods, can be divided into: systemic exposure equipment; oral and nasal inhalation exposure equipment; ex vivo cells exposed to the equipment; special Special exposure to poisoning equipment, such as virus infection equipment; according to different poisoning substances, we can be divided into: cigarette exposure system, VOC exposure system, nanoparticle exposure system and so on.
However, different types of poisoning equipment, if they have almost the same or similar structural units according to their system composition, such as system power unit - air compressor; poisoning material supply unit - generator; exposure of exposed substances The poisoning unit - the poisoning chamber; the environmental monitoring and control unit for the poisoning process - the monitoring unit; the sample analysis sampling unit and the poisoning material recovery processing unit. Among them, it is not difficult to see that the main difference between different types of poisoning equipment is the difference in the exposed unit (ie, the poisoning chamber) or the difference in the generator. The other structural units are not much different or even interchangeable. Such as air compressors, environmental monitors and exhaust gas treatment units. Understand this, we only need to select the various poisoning units that meet the experimental requirements according to our own experimental content. When there are multiple kinds of poisoning methods or requirements for poisoning substances, we can let the system share the same requirements and functions. The unit is designed to achieve maximum savings in the purpose of optimizing the system.
After learning about this, we will briefly introduce some of the brands that are common to everyone, so that you can have a background understanding when you choose the instrument. At present, there are many and more influential companies on the market, such as CH Technologies (hereinafter referred to as CHT), TSE systems (hereinafter referred to as TSE), Japan SIBATA, and CULTEX in Germany.
CHT is a well-known toxicology product development company in the United States. It was founded in 1988 by toxicologist Rudolph J. Jaeger. It is mainly based on mouth and nose inhalation and poisoning equipment, while its systemic exposure to poisoning products is very simple. Cell-infected products. The company's main feature is the program and cooperation. Due to the professional characteristics of Rudolph J. Jaege, CHT is mainly in the United States to provide solutions for solving experiments, and the specific equipment supply mainly comes from various professional companies around the world, such as The aerosol generator may come directly from BGI, the engineering design may come from S&S, and its core product is the design and production of the mouth-nose exposure chamber (including animal survival tube). The company's current main business is still in the United States, mainly in the form of agents in the country, currently there are many companies in the country to represent their products.
TSE is a German professional animal instrument company founded in 1989. The company has three major businesses, according to its primary and secondary: animal metabolism products, animal behavior products, animal inhalation and poisoning products. Inhaled poisoning products are relatively complete, from systemic exposure to exposure, oral and nasal inhalation to exposure to cell exposure. The company's products are characterized by compatibility, as there are many types of products in the field of animal experiments, especially behavioral and metabolic products that are sometimes even compatible and can be used in combination.
SIBATA is a world-renowned instrument manufacturer founded in 1921. The company has significant influence in multidisciplinary fields such as medical, chemical, food, environmental and animal experiments. The inhaled poisoning products are very complete, not only have systemic exposure, oral and nasal inhalation exposure, and complete system of exposure to ex vivo cells, including various types of generators, such as liquid aerosol generators, particulate dust gas. Sol generators, nanoparticle generators, VOC generators, and the like. At the same time, it also specially developed various special-purpose exposed poisoning products, such as virus infection and poisoning equipment, bacterial exposure and poisoning products, fish water exposure and exposure, and even radioisotope exposure and poisoning products. The company's products are characterized by safety and science. Its animal products are concentrated in the expansion of medical and environmental products. Because of its extensive influence in the field of chemical and environmental monitoring and analysis, its core technology for inhalation and exposure monitoring and analysis, exposure chamber The technology is more scientific and complete, and the system is safer to use. Due to its numerous patented technologies, its products have a great impact on the development of domestic exposure and exposure technologies, such as integrated negative pressure safety cabinet technology for mouth and nose inhalation systems.
CULTEX is a professional dye research and development production company founded by Dr. Ulrich Mohr, a gas exposure and exposure expert, which was established in 2007. The company's first transwell membrane technology, developed the Cultex cell in vitro exposure system In vitro exposure system, as the originator and leader of this technology, currently provides CULTEX various types of equipment for most of the world's ex vivo exposure laboratories. The company is characterized by professionalism and innovation, specializing in gas exposure to ex vivo cells, and its continuous technological innovation and application has always maintained its leading position in this field. It should be noted that CULTEX and SIBATA are important partners in the field of inhalation, and many products of CULTEX are designed and manufactured by SIBATA technology.
In short, the inhalation exposure experimental equipment is a complex and flexible system, which is different from the laboratory routine production equipment in that its structure and application are closely related, it can be said that an experiment corresponds to a system, almost every The set of products is a set of customized and perfect experimental solutions. Not only that, but the security of its application has always been a subject of widespread concern. Here, this article can only give the reader a brief introduction, how to use or purchase the inhalation system, and more detailed and careful communication with relevant professionals to find the most suitable solution.