Han Chunyu, an associate professor at Hebei University of Science and Technology, has continued to controversy. On August 8, the "Nature" website published a message saying that more and more scientists complained that they could not repeat the results of Han Chunyu's thesis, but several Chinese scientists who did not want to be named said to Nature that Han Chunyu's The experiment can be repeated. On May 2, 2016, Han Chunyu, an associate professor of life sciences at the College of Biological Sciences and Engineering, Hebei University of Science and Technology, published a paper in Nature and Biotechnology, introducing the team's newly invented gene editing technology, NgAgo-gDNA. The gene editing technology discovered by Associate Professor Han Chunyu and his research team at Hebei University of Science and Technology, unlike the current hot CRISPR-Cas9 technology, is considered to have unique advantages and has great potential in the future. However, this highly regarded result was accused of being “unrepeatable†after more than a month and was questioned by many parties. Subsequently, Pooran Dewari, a postdoctoral fellow in molecular biology at the MRC Centre for Regenerative Medicine in the UK, launched an online survey and published the results on August 4th. Organize Addgene. Han Chunyu Devali said that Han Chunyu's plasmid submitted to Addgene has been requested by the world's laboratories nearly 400 times. The researchers are excited to test the genetic editing application of NgAgo. However, as of August 1, 2016, a total of 165 respondents answered that only one of the 88 respondents confirmed that an insertion defect was successfully formed at the target site. At the same time, 41 respondents attempted to use this technique for epitope tagging, but only one could detect the insertion of a marker at the target site. Overall, 64% of researchers are dissatisfied with the new method, and 65% want someone to optimize the operation of NgAgo. Devali believes that more time is needed to optimize NgAgo. He recommends that researchers engaged in related work openly discuss the topic online and share the research results with you. On July 29th, Gaétan Burgio, a professor at the Australian National University School of Medicine, Biology and Environment, published his own experimental data and conclusion analysis of NgAgo gene in mice for nearly two months. He also said that after many attempts, he still found no evidence that NgAgo could perform genome editing. And NgAgo seems to need to work under the experimental conditions above 50 °C, which is contradictory to the 37 °C normal temperature in Han Chunyu's article. Bargio once told Caixin reporter, "I think this can already indicate that Han Chunyu's research is problematic. I have already called on Han Chunyu to disclose the specific raw data and experimental conditions to prove that his article is no problem. of." Lluis Montoliu, former president of the International Association of Genetically Modified Technology, sent an email to his colleague at the International Genetically Modified Organisation, citing the case of Balggio, suggesting "abandon any project on NgAgo."
Shandong Chunyu Water-saving Irrigation Equipment Co., Ltd., founded in 2011, is located in Laiwu High-tech Zone, Jinan City. It is a high-tech enterprise focusing on innovative and efficient emitter mold manufacturing and emitter product research and development and production. After nearly ten years of innovation and development, it is the invisible champion enterprise in Shandong Province, and now it is in a leading position in this field in China.
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