Release date: 2015-07-23 French children with HIV are still healthy after 12 years of treatment The International AIDS Conference in Vancouver, Canada, today reported an unusual story: French children with HIV were still healthy after 12 years of treatment, and the incident was reported to help those who did not receive antiretroviral (ARV) medication. HIV-infected people control their condition and give AIDS vaccine developers some inspiration. In 1996, a French AIDS-infected child who was diagnosed at birth began taking anti-AIDS drugs. But at the age of 6, her parents stopped her treatment regardless of the doctor's advice. Twelve years later, the French child is still healthy and no HIV is detected in the blood. French children and Mississippi baby Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, said he is interested in the French case, which has similarities with Mississippi children, which may be related to the immune system of young people. The case of the Mississippi Baby is a happy thing, and perhaps to some extent, the two children control HIV in a similar way. We need to have a completely open mind. The incident brought some new positive factors to the early reports of self-controlled management of HIV-infected people who were referred to as “control elites†who did not receive treatment but were able to suppress the virus, or after treatment like “Mississippi Baby†Good control of HIV. "Mississippi Baby" stopped taking antiretroviral drugs when it was in August. In 2013, many researchers thought that the "Mississippi Baby" may have been "cure", but the HIV virus was again in her after 27 months of treatment. Recurrence on the body. But this time it is obvious that this French child is not cured. Investigators found strong HIV DNA signals in her immune cells and easily induced the virus. Asier Sáez-Cirión, a virus immunologist at the Pasteur Institute in Paris, reported that the French girl was the first to be able to maintain a long-term infection after being diagnosed with HIV, but we don’t know how it is. occurring. Why do infected people maintain the relief of infection after stopping treatment? Scientists give three reasons Asier Sáez-Cirión said in a 2013 study, “Most people follow the same treatments without controlling infection, but a few people will. 5% to 15% of patients can get a functional cure, which means They are no longer in need of medical treatment by attacking the virus after infection. They still carry HIV, it is not eradicating HIV, but a relief of some infection. So how do patients alleviate HIV infection? The clues came from an adult AIDS patient group, which was crowned with Visconti cohort, a group of patients who had no signs of viral resuscitation for many years after stopping antiretroviral therapy. A report published by Asier Sáez-Cirión and colleagues in PLOS Pathogens in 2013 said that those who were diagnosed with HIV early, if they were treated immediately, could extend their life for three years. In the study at the time, the patient was able to control HIV for an average of 7 years after stopping treatment. At present, Visconti has added a new case group to the same group, with a total of 20 people. Although there is no single factor that can explain the extraordinary ability of HIV control in controlling elites, many people with high levels of CD8 lymphocytes (identifying and eliminating HIV-infected cells) are affected by genetic factors. After treatment, such as the Visconti cohort, the virus level increased rapidly after infection, and the immune system deteriorated rapidly. Paradoxically, many people with a genetic background are more vulnerable to the HIV immune response. So why can patients maintain the relief of infection after stopping treatment? Scientists give three hypotheses. 1. The human virus database has no chance to be filled with HIV Sáez-Cirión thinks they can get help from a more primitive, less powerful innate immune system. The researchers assume that the human body contains a very small pool of viral DNA, and the human immune system may be large enough to contain the HIV virus. Visconti's members of the same group were treated quickly after infection so that the virus pool had no chance to be filled. 2. CD4 white blood cells are weak, causing the virus to have fewer infection targets. On the other hand, it may be a bit unreasonable, Sáez-Cirión said that the weak immune response of the controller after treatment helps to control the size of the virus pool before receiving the drug. The HIV virus preferentially targets and infects CD4 white blood cells, and the weak CD4 means that the virus has fewer infection targets. 3. The infection ability is not strong after virus mutation Sáez-Cirión gives a third possibility: some post-treatment controllers may be infected with relatively weak viruses, which may be mutated due to propensity error correction. Source: Bio-Exploration Brama Fillet,Frozen Brama Fillet,Brama Brama Fillet,Frozen Brama Brama Fillet Zhejiang Zhoushan Jiaze Aquatic Co., Ltd. , https://www.tianjia-aquatics.com