Bioactive materials can repair spinal cord injury

December 04, 2015 Source: Technology Daily

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Solving world-class medical problems. Recently, Li Xiaoguang, a professor of the Capital Medical University and Beijing University of Aeronautics and Astronautics, and his research team demonstrated for the first time that “the application of bioactive materials to activate endogenous stem cells to repair spinal cord injury” and the use of genome-wide expression profiling to clarify the mechanism and solve the problem. Paraplegia is a worldwide problem, and related results are published online in the Proceedings of the National Academy of Sciences. (Bio Valley Bioon.com)

The researchers said that the main reason for the inability of the spinal cord to regenerate is that the microenvironment of the local central nervous system is not conducive to nerve regeneration. This is a common understanding in the medical field in the past 100 years. However, recent studies have found that neural stem cells in the dormant state of the adult central nervous system still retain potential regenerative capacity. Therefore, it is possible to promote regeneration after spinal cord injury by changing the microenvironment of the damaged part by operation.

Researchers use biological materials to activate endogenous neural stem cells in adult animals, induce them to differentiate into functional neurons and establish a functional neural circuit with the host spinal cord, ultimately leading to the recovery of paraplegia, avoiding ethical disputes, immune rejection and It reduces the risk of developing tumors and is an ideal way to repair tissues and organs.

At present, the "Spiral Reconstruction Tube" developed by Li Xiaoguang's research team has passed the test of the China Food and Drug Control Research Institute. The indicators are in line with international standards and have the basic conditions for conducting clinical trial research.

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